FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Mnk2
反应性
Human,Mouse,Rat
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
51kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from the Internal region of human Mnk2.
特异性
Mnk2 Polyclonal Antibody detects endogenous levels of Mnk2 protein.
基因名称
MKNK2
蛋白名称
MAP kinase-interacting serine/threonine-protein kinase 2
别名
MKNK2;GPRK7;MNK2;MAP kinase-interacting serine/threonine-protein kinase 2;MAP kinase signal-integrating kinase 2;MAPK signal-integrating kinase 2;Mnk2
Organism-1
Human
基因ID-1
2872
SwissProt-1
Q9HBH9
Organism-2
Mouse
基因ID-2
17347
SwissProt-2
Q8CDB0
Organism-3
Rat
基因ID-3
299618
SwissProt-3
Q5U2N4
背景
MAP kinase interacting serine/threonine kinase 2(MKNK2) Homo sapiens This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex.
细胞定位
[Isoform 2]: Nucleus, PML body.; [Isoform 1]: Cytoplasm.
