FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ML-IAP
反应性
Human,Mouse
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
21kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human ML-IAP. AA range:162-211
特异性
ML-IAP Polyclonal Antibody detects endogenous levels of ML-IAP protein.
基因名称
BIRC7
蛋白名称
Baculoviral IAP repeat-containing protein 7
别名
BIRC7;KIAP;LIVIN;MLIAP;RNF50;Baculoviral IAP repeat-containing protein 7;Kidney inhibitor of apoptosis protein;KIAP;Livin;Melanoma inhibitor of apoptosis protein;ML-IAP;RING finger protein 50
Organism-1
Human
基因ID-1
79444
SwissProt-1
Q96CA5
Organism-2
Mouse
SwissProt-2
A2AWP0
背景
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013],
细胞定位
Nucleus . Cytoplasm . Golgi apparatus . Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
