FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
mGluR-8
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
100kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human mGluR8. AA range:841-890
特异性
mGluR-8 Polyclonal Antibody detects endogenous levels of mGluR-8 protein.
基因名称
GRM8
蛋白名称
Metabotropic glutamate receptor 8
别名
GRM8;GPRC1H;MGLUR8;Metabotropic glutamate receptor 8;mGluR8
Organism-1
Human
基因ID-1
2918
SwissProt-1
O00222
Organism-2
Mouse
SwissProt-2
P47743
Organism-3
Rat
基因ID-3
60590
SwissProt-3
P70579
背景
glutamate metabotropic receptor 8(GRM8) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been d
细胞定位
Cell membrane; Multi-pass membrane protein.
