FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
mGluR2
反应性
Human,Mouse,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
96kD
推荐稀释比
IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human GRM2. AA range:241-290
特异性
mGluR2 Polyclonal Antibody detects endogenous levels of mGluR2 protein.
基因名称
GRM2
蛋白名称
Metabotropic glutamate receptor 2
别名
GRM2;GPRC1B;MGLUR2;Metabotropic glutamate receptor 2;mGluR2
Organism-1
Human
基因ID-1
2912
SwissProt-1
Q14416
Organism-2
Mouse
基因ID-2
108068
SwissProt-2
Q14BI2
Organism-3
Rat
基因ID-3
24415
SwissProt-3
P31421
背景
glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite .
