FGF-2 Polyclonal Antibody
¥680.00
MEK Kinase-3 Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2614883
- 产品信息
商品描述
靶点-Target
MEK Kinase-3
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
71kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MAP3K3. AA range:101-150
特异性
MEK Kinase-3 Polyclonal Antibody detects endogenous levels of MEK Kinase-3 protein.
基因名称
MAP3K3
蛋白名称
Mitogen-activated protein kinase kinase kinase 3
别名
MAP3K3;MAPKKK3;MEKK3;Mitogen-activated protein kinase kinase kinase 3;MAPK/ERK kinase kinase 3;MEK kinase 3;MEKK 3
Organism-1
Human
基因ID-1
4215
SwissProt-1
Q99759
Organism-2
Mouse
基因ID-2
26406
SwissProt-2
Q61084
背景
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
细胞定位
cytoplasm,cytosol,
