FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MC1-R
反应性
Human,Mouse
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
35kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MSHR. AA range:268-317
特异性
MC1-R Polyclonal Antibody detects endogenous levels of MC1-R protein.
基因名称
MC1R
蛋白名称
Melanocyte-stimulating hormone receptor
别名
MC1R;MSHR;Melanocyte-stimulating hormone receptor;MSH-R;Melanocortin receptor 1;MC1-R
Organism-1
Human
基因ID-1
4157
SwissProt-1
Q01726
Organism-2
Mouse
SwissProt-2
Q01727
背景
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in de
细胞定位
Cell membrane ; Multi-pass membrane protein .
