FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MBD3
反应性
Human,Mouse
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
33kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270
特异性
MBD3 Polyclonal Antibody detects endogenous levels of MBD3 protein.
基因名称
MBD3
蛋白名称
Methyl-CpG-binding domain protein 3
别名
MBD3;Methyl-CpG-binding domain protein 3;Methyl-CpG-binding protein MBD3
Organism-1
Human
基因ID-1
53615
SwissProt-1
O95983
Organism-2
Mouse
基因ID-2
17192
SwissProt-2
Q9Z2D8
背景
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
细胞定位
Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
