FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MAD2
反应性
Human,Mouse
应用
WB,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
25kD
推荐稀释比
WB 1:500-1:2000;IP 1:200-500;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MAD2L1. AA range:91-140
特异性
MAD2 Polyclonal Antibody detects endogenous levels of MAD2 protein.
基因名称
MAD2L1
蛋白名称
Mitotic spindle assembly checkpoint protein MAD2A
别名
MAD2L1;MAD2;Mitotic spindle assembly checkpoint protein MAD2A;HsMAD2;Mitotic arrest deficient 2-like protein 1;MAD2-like protein 1
Organism-1
Human
基因ID-1
4085
SwissProt-1
Q13257
Organism-2
Mouse
SwissProt-2
Q9Z1B5
背景
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Chromosome, centromere, kinetochore. Cytoplasm . Cytoplasm, cytoskeleton, spindle pole. Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. Sequestered to the cytoplasm upon interaction with isoform 3 of MAD1L1 (PubMed:19010891). .
