FGF-2 Polyclonal Antibody
¥680.00
Lunatic Fringe Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2614792
- 产品信息
商品描述
靶点-Target
Lunatic Fringe
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
42kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human LFNG. AA range:121-170
特异性
Lunatic Fringe Polyclonal Antibody detects endogenous levels of Lunatic Fringe protein.
基因名称
LFNG
蛋白名称
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
别名
LFNG;Beta-1;3-N-acetylglucosaminyltransferase lunatic fringe;O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Organism-1
Human
基因ID-1
3955
SwissProt-1
Q8NES3
Organism-2
Mouse
基因ID-2
16848
SwissProt-2
O09010
Organism-3
Rat
基因ID-3
170905
SwissProt-3
Q924T4
背景
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
