FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
KMT1B
反应性
Human,Mouse
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
46kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SUV39H2. AA range:111-160
特异性
KMT1B Polyclonal Antibody detects endogenous levels of KMT1B protein.
基因名称
SUV39H2
蛋白名称
Histone-lysine N-methyltransferase SUV39H2
别名
SUV39H2;KMT1B;Histone-lysine N-methyltransferase SUV39H2;Histone H3-K9 methyltransferase 2;H3-K9-HMTase 2;Lysine N-methyltransferase 1B;Suppressor of variegation 3-9 homolog 2;Su;var;3-9 homolog 2
Organism-1
Human
基因ID-1
79723
SwissProt-1
Q9H5I1
Organism-2
Mouse
基因ID-2
64707
SwissProt-2
Q9EQQ0
背景
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,domain:Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin.,function:Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.,similarity:Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.,similarity:Contains 1 chromo domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,subcellular location:Associates with centromeric constitutive heterochromatin.,subunit:Interacts with SMAD5.,
细胞定位
Nucleus . Chromosome, centromere . Associates with centromeric constitutive heterochromatin. .
