FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
KIR6.2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
40kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Kir6.2. AA range:190-239
特异性
KIR6.2 Polyclonal Antibody detects endogenous levels of KIR6.2 protein.
基因名称
KCNJ11
蛋白名称
ATP-sensitive inward rectifier potassium channel 11
别名
KCNJ11;ATP-sensitive inward rectifier potassium channel 11;IKATP;Inward rectifier K;+;channel Kir6.2;Potassium channel;inwardly rectifying subfamily J member 11
Organism-1
Human
基因ID-1
3767
SwissProt-1
Q14654
Organism-2
Mouse
基因ID-2
16514
SwissProt-2
Q61743
Organism-3
Rat
基因ID-3
83535
SwissProt-3
P70673
背景
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced trans
细胞定位
Membrane; Multi-pass membrane protein.
