FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
KCNQ4
反应性
Human,Mouse
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
80kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human KCNQ4. AA range:644-693
特异性
KCNQ4 Polyclonal Antibody detects endogenous levels of KCNQ4 protein.
基因名称
KCNQ4
蛋白名称
Potassium voltage-gated channel subfamily KQT member 4
别名
KCNQ4;Potassium voltage-gated channel subfamily KQT member 4;KQT-like 4;Potassium channel subunit alpha KvLQT4;Voltage-gated potassium channel subunit Kv7.4
Organism-1
Human
基因ID-1
9132
SwissProt-1
P56696
Organism-2
Mouse
基因ID-2
60613
SwissProt-2
Q9JK97
背景
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Basal cell membrane; Multi-pass membrane protein. Situated at the basal membrane of cochlear outer hair cells. .
