FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
KCNH1
反应性
Human,Mouse,Rat
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
110kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human KCNH1. AA range:720-769
特异性
KCNH1 Polyclonal Antibody detects endogenous levels of KCNH1 protein.
基因名称
KCNH1
蛋白名称
Potassium voltage-gated channel subfamily H member 1
别名
KCNH1;EAG;EAG1;Potassium voltage-gated channel subfamily H member 1;Ether-a-go-go potassium channel 1;EAG channel 1;h-eag;hEAG1;Voltage-gated potassium channel subunit Kv10.1
Organism-1
Human
基因ID-1
3756
SwissProt-1
O95259
Organism-2
Mouse
基因ID-2
16510
SwissProt-2
Q60603
Organism-3
Rat
基因ID-3
65198
SwissProt-3
Q63472
背景
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided
细胞定位
Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic density membrane . Early endosome membrane . Perinuclear KCNH1 is located to NPC-free islands.
