FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
JMJD2B
反应性
Human,Mouse
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
122kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human KDM4B. AA range:351-400
特异性
JMJD2B Polyclonal Antibody detects endogenous levels of JMJD2B protein.
基因名称
KDM4B
蛋白名称
Lysine-specific demethylase 4B
别名
KDM4B;JHDM3B;JMJD2B;KIAA0876;Lysine-specific demethylase 4B;JmjC domain-containing histone demethylation protein 3B;Jumonji domain-containing protein 2B
Organism-1
Human
基因ID-1
23030
SwissProt-1
O94953
Organism-2
Mouse
SwissProt-2
Q91VY5
背景
cofactor:Binds 1 Fe(2+) ion per subunit.,domain:The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.,function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.,similarity:Belongs to the JHDM3 histone demethylase family.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 2 PHD-type zinc fingers.,similarity:Contains 2 Tudor domains.,
细胞定位
Nucleus .
