FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
JIP-3
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
170kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human JIP3. AA range:621-670
特异性
JIP-3 Polyclonal Antibody detects endogenous levels of JIP-3 protein.
基因名称
MAPK8IP3
蛋白名称
C-Jun-amino-terminal kinase-interacting protein 3
别名
MAPK8IP3;JIP3;KIAA1066;C-Jun-amino-terminal kinase-interacting protein 3;JIP-3;JNK-interacting protein 3;JNK MAP kinase scaffold protein 3;Mitogen-activated protein kinase 8-interacting protein 3
Organism-1
Human
基因ID-1
23162
SwissProt-1
Q9UPT6
Organism-2
Mouse
基因ID-2
30957
SwissProt-2
Q9ESN9
背景
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Golgi apparatus . Cytoplasmic vesicle . Cell projection, growth cone . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation. .
