FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
JIP-1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
113 78kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human JIP1. AA range:69-118
特异性
JIP-1 Polyclonal Antibody detects endogenous levels of JIP-1 protein.
基因名称
MAPK8IP1
蛋白名称
C-Jun-amino-terminal kinase-interacting protein 1
别名
MAPK8IP1;IB1;JIP1;PRKM8IP;C-Jun-amino-terminal kinase-interacting protein 1;JIP-1;JNK-interacting protein 1;Islet-brain 1;IB-1;JNK MAP kinase scaffold protein 1;Mitogen-activated protein kinase 8-interacting protein 1
Organism-1
Human
基因ID-1
9479
SwissProt-1
Q9UQF2
Organism-2
Mouse
基因ID-2
19099
SwissProt-2
Q9WVI9
Organism-3
Rat
基因ID-3
116457
SwissProt-3
Q9R237
背景
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011],
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Endoplasmic reticulum membrane. Mitochondrion membrane. Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). .
