FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
IRTKS
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
57kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human BAIAP2L1. AA range:111-160
特异性
IRTKS Polyclonal Antibody detects endogenous levels of IRTKS protein.
基因名称
BAIAP2L1
蛋白名称
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
别名
BAIAP2L1;IRTKS;Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1;BAI1-associated protein 2-like protein 1;Insulin receptor tyrosine kinase substrate
Organism-1
Human
基因ID-1
55971
SwissProt-1
Q9UHR4
Organism-2
Mouse
基因ID-2
66898
SwissProt-2
Q9DBJ3
Organism-3
Rat
基因ID-3
304282
SwissProt-3
Q3KR97
背景
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal fo
细胞定位
Cytoplasm, cytoskeleton . Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
