FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
hnRNP A1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
33kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human hnRNP A1. AA range:51-100
特异性
hnRNP A1 Polyclonal Antibody detects endogenous levels of hnRNP A1 protein.
基因名称
HNRNPA1
蛋白名称
Heterogeneous nuclear ribonucleoprotein A1
别名
HNRNPA1;HNRPA1;Heterogeneous nuclear ribonucleoprotein A1;hnRNP A1;Helix-destabilizing protein;Single-strand RNA-binding protein;hnRNP core protein A1
Organism-1
Human
基因ID-1
3178
SwissProt-1
P09651
Organism-2
Mouse
基因ID-2
15382
SwissProt-2
P49312
Organism-3
Rat
基因ID-3
29578
SwissProt-3
P04256
背景
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016],
细胞定位
Nucleus . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661). .; Cytoplasm . (Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner. .; Nucleus . (Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus. .
