FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HIRA
反应性
Human,Mouse
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
112kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human HIRA. AA range:521-570
特异性
HIRA Polyclonal Antibody detects endogenous levels of HIRA protein.
基因名称
HIRA
蛋白名称
Protein HIRA
别名
HIRA;DGCR1;HIR;TUPLE1;Protein HIRA;TUP1-like enhancer of split protein 1
Organism-1
Human
基因ID-1
7290
SwissProt-1
P54198
Organism-2
Mouse
基因ID-2
15260
SwissProt-2
Q61666
背景
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus. Nucleus, PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
