FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HDAC7
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
103kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human HDAC7A. AA range:121-170
特异性
HDAC7 Polyclonal Antibody detects endogenous levels of HDAC7 protein.
基因名称
HDAC7
蛋白名称
Histone deacetylase 7
别名
HDAC7;HDAC7A;Histone deacetylase 7;HD7;Histone deacetylase 7A;HD7a
Organism-1
Human
基因ID-1
51564
SwissProt-1
Q8WUI4
Organism-2
Mouse
基因ID-2
56233
SwissProt-2
Q8C2B3
Organism-3
Rat
SwissProt-3
Q99P96
背景
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
