FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HAT1
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
49kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human HAT. AA range:331-380
特异性
HAT1 Polyclonal Antibody detects endogenous levels of HAT1 protein.
基因名称
HAT1
蛋白名称
Histone acetyltransferase type B catalytic subunit
别名
HAT1;KAT1;Histone acetyltransferase type B catalytic subunit;Histone acetyltransferase 1
Organism-1
Human
基因ID-1
8520
SwissProt-1
O14929
Organism-2
Mouse
基因ID-2
107435
SwissProt-2
Q8BY71
Organism-3
Rat
基因ID-3
296501
SwissProt-3
Q5M939
背景
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009],
细胞定位
[Isoform A]: Nucleus matrix . Mitochondrion .; [Isoform B]: Cytoplasm . Nucleus . Nucleus matrix . Nucleus, nucleoplasm . Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. .
