FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MSH6
反应性
Human,Mouse,Monkey
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
170kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MSH6. AA range:341-390
特异性
GTBP Polyclonal Antibody detects endogenous levels of GTBP protein.
基因名称
MSH6
蛋白名称
DNA mismatch repair protein Msh6
别名
MSH6;GTBP;DNA mismatch repair protein Msh6;hMSH6;G/T mismatch-binding protein;GTBP;GTMBP;MutS-alpha 160 kDa subunit;p160
Organism-1
Human
基因ID-1
2956
SwissProt-1
P52701
Organism-2
Mouse
基因ID-2
17688
SwissProt-2
P54276
背景
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013],
细胞定位
Nucleus . Chromosome . Associates with H3K36me3 via its PWWP domain.
