FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GlyRβ
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
56kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human GLRB. AA range:211-260
特异性
GlyRβ Polyclonal Antibody detects endogenous levels of GlyRβ protein.
基因名称
GLRB
蛋白名称
Glycine receptor subunit beta
别名
GLRB;Glycine receptor subunit beta;Glycine receptor 58 kDa subunit
Organism-1
Human
基因ID-1
2743
SwissProt-1
P48167
Organism-2
Mouse
基因ID-2
14658
SwissProt-2
P48168
Organism-3
Rat
基因ID-3
25456
SwissProt-3
P20781
背景
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
细胞定位
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. .
