FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GRID2
反应性
Human,Mouse,Rat
应用
WB,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
113kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human GRID2. AA range:831-880
特异性
GluR-δ2 Polyclonal Antibody detects endogenous levels of GluR-δ2 protein.
基因名称
GRID2
蛋白名称
Glutamate receptor delta-2 subunit
别名
GRID2;GLURD2;Glutamate receptor delta-2 subunit;GluR delta-2 subunit
Organism-1
Human
基因ID-1
2895
SwissProt-1
O43424
Organism-2
Mouse
基因ID-2
14804
SwissProt-2
Q61625
Organism-3
Rat
基因ID-3
79220
SwissProt-3
Q63226
背景
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein .
