FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Girdin
反应性
Human,Mouse
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
216kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Girdin. AA range:1383-1432
特异性
Girdin Polyclonal Antibody detects endogenous levels of Girdin protein.
基因名称
CCDC88A
蛋白名称
Girdin
别名
CCDC88A;APE;GRDN;KIAA1212;Girdin;Akt phosphorylation enhancer;APE;Coiled-coil domain-containing protein 88A;G alpha-interacting vesicle-associated protein;GIV;Girders of actin filament;Hook-related protein 1;HkRP1
Organism-1
Human
基因ID-1
55704
SwissProt-1
Q3V6T2
Organism-2
Mouse
基因ID-2
108686
SwissProt-2
Q5SNZ0
背景
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
细胞定位
Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Cytoplasmic vesicle . Cell projection, lamellipodium . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to the cytosol in unstimulated cells while EGF stimulation promotes membrane localization and guanine nucleotide exchange factor activity (PubMed:27864364). Localizes to the cell membrane through interaction with phosphoinositides (PubMed:16139227, PubMed:15882442). .
