FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GALR2
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
42kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human GALR2. AA range:201-250
特异性
GALR2 Polyclonal Antibody detects endogenous levels of GALR2 protein.
基因名称
GALR2
蛋白名称
Galanin receptor type 2
别名
GALR2;GALNR2;Galanin receptor type 2;GAL2-R;GALR-2
Organism-1
Human
基因ID-1
8811
SwissProt-1
O43603
Organism-2
Mouse
基因ID-2
14428
SwissProt-2
O88854
Organism-3
Rat
基因ID-3
100910349
SwissProt-3
O08726
背景
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simul
细胞定位
Cell membrane; Multi-pass membrane protein.
