FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FoxK1
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
78kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human FOXK1. AA range:681-730
特异性
FoxK1 Polyclonal Antibody detects endogenous levels of FoxK1 protein.
基因名称
FOXK1
蛋白名称
Forkhead box protein K1
别名
FOXK1;MNF;Forkhead box protein K1;Myocyte nuclear factor;MNF
Organism-1
Human
基因ID-1
221937
SwissProt-1
P85037
Organism-2
Mouse
基因ID-2
17425
SwissProt-2
P42128
背景
function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.,PTM:Phosphorylated.,similarity:Contains 1 FHA domain.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with SIN3B to form a complex which represses transcription.,tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.,
细胞定位
Nucleus . Cytoplasm . Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164). .
