FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Fish
反应性
Human,Mouse
应用
IHC,IF,WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
125kD
推荐稀释比
IHC 1:100-500;IF/ICC1:100-500;WB 1:500-2000;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from the N-terminal region of human Fish.
特异性
Fish Polyclonal Antibody detects endogenous levels of Fish protein.
基因名称
SH3PXD2A
蛋白名称
SH3 and PX domain-containing protein 2A
别名
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5;SH3 and PX domain-containing protein 2A;Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains
Organism-1
Human
基因ID-1
9644
SwissProt-1
Q5TCZ1
Organism-2
Mouse
基因ID-2
14218
SwissProt-2
O89032
背景
domain:The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19.,domain:The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2).,function:Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.,PTM:Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SH3PXD2 family.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 5 SH3 domains.,subcellular location:Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.,subunit:Interacts with ADAM12, ADAM15 and ADAM19.,tissue specificity:Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.,
细胞定位
Cytoplasm. Cell projection, podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
