FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FBN1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
312kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Fibrillin-1. AA range:2811-2860
特异性
FBN1 Polyclonal Antibody detects endogenous levels of FBN1 protein.
基因名称
FBN1
蛋白名称
Fibrillin-1
别名
FBN1;FBN;Fibrillin-1
Organism-1
Human
基因ID-1
2200
SwissProt-1
P35555
Organism-2
Mouse
SwissProt-2
Q61554
背景
This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016],
细胞定位
Secreted . Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin (PubMed:24982166). .; [Fibrillin-1]: Secreted, extracellular space, extracellular matrix .; [Asprosin]: Secreted . Secreted by white adipose tissue and circulates in the plasma. .
