FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Factor I
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
Full lenth:66kD,heavy chain:50-58kD
推荐稀释比
WB 1:500-2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CFI. AA range:441-490
特异性
Factor I Polyclonal Antibody detects endogenous levels of Factor I protein.
基因名称
CFI
蛋白名称
Complement factor I
别名
CFI;IF;Complement factor I;C3B/C4B inactivator
Organism-1
Human
基因ID-1
3426
SwissProt-1
P05156
Organism-2
Mouse
SwissProt-2
Q61129
背景
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by Ref
细胞定位
Secreted, extracellular space. Secreted .
