FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ERI1
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
37kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human ERI1. AA range:261-310
特异性
ERI1 Polyclonal Antibody detects endogenous levels of ERI1 protein.
基因名称
ERI1
蛋白名称
3'-5' exoribonuclease 1
别名
ERI1;3'EXO;THEX1;3'-5' exoribonuclease 1;3'-5' exonuclease ERI1;Eri-1 homolog;Histone mRNA 3'-end-specific exoribonuclease;Histone mRNA 3'-exonuclease 1;Protein 3'hExo;HEXO
Organism-1
Human
基因ID-1
90459
SwissProt-1
Q8IV48
Organism-2
Mouse
基因ID-2
67276
SwissProt-2
Q7TMF2
Organism-3
Rat
基因ID-3
361159
SwissProt-3
Q5FVR4
背景
cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.,function:RNA exonuclease that binds to the 3'-end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for 5.8S rRNA 3'-end processing.,sequence caution:Translated as Leu.,similarity:Contains 1 exonuclease domain.,similarity:Contains 1 SAP domain.,subunit:Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Requires the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Also binds to 5.8s ribosomal RNA.,
细胞定位
Cytoplasm . Nucleus . Nucleus, nucleolus .
