FGF-2 Polyclonal Antibody
¥680.00
Endophilin I Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2613940
- 产品信息
商品描述
靶点-Target
Endophilin I
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
39kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from Endophilin I . at AA range: 30-110
特异性
Endophilin I Polyclonal Antibody detects endogenous levels of Endophilin I protein.
基因名称
SH3GL2
蛋白名称
Endophilin-A1
别名
SH3GL2;CNSA2;SH3D2A;Endophilin-A1;EEN-B1;Endophilin-1;SH3 domain protein 2A;SH3 domain-containing GRB2-like protein 2
Organism-1
Human
基因ID-1
6456
SwissProt-1
Q99962
Organism-2
Mouse
基因ID-2
20404
SwissProt-2
Q62420
Organism-3
Rat
基因ID-3
116743
SwissProt-3
O35179
背景
domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.,function:Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.,miscellaneous:HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation.,similarity:Belongs to the endophilin family.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subcellular location:Concentrated in presynaptic nerve terminals in neurons.,subunit:Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP.,tissue specificity:Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.,
细胞定位
Cytoplasm . Membrane ; Peripheral membrane protein . Early endosome . Cell junction, synapse, presynapse .
