FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Dyskerin
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
57kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Dyskerin. AA range:171-220
特异性
Dyskerin Polyclonal Antibody detects endogenous levels of Dyskerin protein.
基因名称
DKC1
蛋白名称
H/ACA ribonucleoprotein complex subunit 4
别名
DKC1;NOLA4;H/ACA ribonucleoprotein complex subunit 4;CBF5 homolog;Dyskerin;Nopp140-associated protein of 57 kDa;Nucleolar protein NAP57;Nucleolar protein family A member 4;snoRNP protein DKC1
Organism-1
Human
基因ID-1
1736
SwissProt-1
O60832
Organism-2
Mouse
基因ID-2
245474
SwissProt-2
Q9ESX5
Organism-3
Rat
基因ID-3
170944
SwissProt-3
P40615
背景
dyskerin pseudouridine synthase 1(DKC1) Homo sapiens This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
细胞定位
[Isoform 1]: Nucleus, nucleolus . Nucleus, Cajal body . Also localized to Cajal bodies (coiled bodies). .; [Isoform 3]: Cytoplasm .
