FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
DYR1A
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
90kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human DYR1A. AA range:21-70
特异性
Dyrk1A Polyclonal Antibody detects endogenous levels of Dyrk1A protein.
基因名称
DYRK1A
蛋白名称
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
别名
DYRK1A;DYRK;MNB;MNBH;Dual specificity tyrosine-phosphorylation-regulated kinase 1A;Dual specificity YAK1-related kinase;HP86;Protein kinase minibrain homolog;MNBH;hMNB
Organism-1
Human
基因ID-1
1859
SwissProt-1
Q13627
Organism-2
Mouse
基因ID-2
13548
SwissProt-2
Q61214
Organism-3
Rat
基因ID-3
25255
SwissProt-3
Q63470
背景
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' co
细胞定位
Nucleus . Nucleus speckle .
