FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
DOC-1
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
20kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CDKAP1. AA range:51-100
特异性
DOC-1 Polyclonal Antibody detects endogenous levels of DOC-1 protein.
基因名称
CDK2AP1
蛋白名称
Cyclin-dependent kinase 2-associated protein 1
别名
CDK2AP1;CDKAP1;DOC1;Cyclin-dependent kinase 2-associated protein 1;CDK2-associated protein 1;Deleted in oral cancer 1;DOC-1;Putative oral cancer suppressor
Organism-1
Human
基因ID-1
8099
SwissProt-1
O14519
Organism-2
Mouse
基因ID-2
13445
SwissProt-2
O35207
背景
cyclin dependent kinase 2 associated protein 1(CDK2AP1) Homo sapiens The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
细胞定位
nucleus,perinuclear region of cytoplasm,
