FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
DIO3
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
31kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human DIO3. AA range:17-66
特异性
DIO3 Polyclonal Antibody detects endogenous levels of DIO3 protein.
基因名称
DIO3
蛋白名称
Type III iodothyronine deiodinase
别名
DIO3;ITDI3;TXDI3;Type III iodothyronine deiodinase;5DIII;DIOIII;Type 3 DI;Type-III 5'-deiodinase
Organism-1
Human
基因ID-1
1735
SwissProt-1
P55073
Organism-2
Mouse
基因ID-2
107585
SwissProt-2
Q91ZI8
Organism-3
Rat
基因ID-3
29475
SwissProt-3
P49897
背景
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei
细胞定位
Cell membrane ; Single-pass type II membrane protein . Endosome membrane ; Single-pass type II membrane protein .
