FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Cyclin A
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
53kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Cyclin A. AA range:221-270
特异性
Cyclin A Polyclonal Antibody detects endogenous levels of Cyclin A protein.
基因名称
CCNA1/CCNA2
蛋白名称
Cyclin-A1/2
别名
CCNA1;Cyclin-A1;CCNA2;CCN1;CCNA;Cyclin-A2;Cyclin-A
Organism-1
Human
基因ID-1
8900;890
SwissProt-1
P78396;P20248
Organism-2
Mouse
基因ID-2
12427;12428
Organism-3
Rat
基因ID-3
295052
SwissProt-3
Q6AY13
背景
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multi
细胞定位
Nucleus .
