FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CRSP130
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
150kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MED23. AA range:1-50
特异性
CRSP130 Polyclonal Antibody detects endogenous levels of CRSP130 protein.
基因名称
MED23
蛋白名称
Mediator of RNA polymerase II transcription subunit 23
别名
MED23;ARC130;CRSP3;DRIP130;KIAA1216;SUR2;Mediator of RNA polymerase II transcription subunit 23;Activator-recruited cofactor 130 kDa component;ARC130;Cofactor required for Sp1 transcriptional activation subunit 3;CRSP complex subu
Organism-1
Human
基因ID-1
9439
SwissProt-1
Q9ULK4
Organism-2
Mouse
基因ID-2
70208
SwissProt-2
Q80YQ2
Organism-3
Rat
SwissProt-3
Q5EB59
背景
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012],
细胞定位
Nucleus .
