FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Crk II
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
40kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CrkII. AA range:187-236
特异性
Crk II Polyclonal Antibody detects endogenous levels of Crk II protein.
基因名称
CRK
蛋白名称
Adapter molecule crk
别名
CRK;Adapter molecule crk;Proto-oncogene c-Crk;p38
Organism-1
Human
基因ID-1
1398
SwissProt-1
P46108
Organism-2
Mouse
基因ID-2
12928
SwissProt-2
Q64010
Organism-3
Rat
基因ID-3
54245
SwissProt-3
Q63768
背景
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .
