FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CHOP
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
19kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CHOP. AA range:15-64
特异性
CHOP Polyclonal Antibody detects endogenous levels of CHOP protein.
基因名称
DDIT3
蛋白名称
DNA damage-inducible transcript 3 protein
别名
DDIT3;CHOP;CHOP10;GADD153;DNA damage-inducible transcript 3 protein;DDIT-3;C/EBP-homologous protein;CHOP;C/EBP-homologous protein 10;CHOP-10;Growth arrest and DNA damage-inducible protein GADD153
Organism-1
Human
基因ID-1
1649
SwissProt-1
P35638
Organism-2
Mouse
基因ID-2
13198
SwissProt-2
P35639
背景
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010],
细胞定位
Cytoplasm . Nucleus . Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. .
