FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CEP57
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
50kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CEP57. AA range:241-290
特异性
CEP57 Polyclonal Antibody detects endogenous levels of CEP57 protein.
基因名称
CEP57
蛋白名称
Centrosomal protein of 57 kDa
别名
CEP57;KIAA0092;TSP57;Centrosomal protein of 57 kDa;Cep57;FGF2-interacting protein;Testis-specific protein 57;Translokin
Organism-1
Human
基因ID-1
9702
SwissProt-1
Q86XR8
Organism-2
Mouse
SwissProt-2
Q8CEE0
背景
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple
细胞定位
Nucleus . Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
