FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CDK1/CDC2
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
34kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CDK1/CDC2. AA range:1-50
特异性
Cdk1/2/3 Polyclonal Antibody detects endogenous levels of Cdk1/2/3 protein.
基因名称
CDK1/CDK2/CDK3
蛋白名称
Cyclin-dependent kinase 1/2/3
别名
CDK1;CDC2;CDC28A;CDKN1;P34CDC2;Cyclin-dependent kinase 1;CDK1;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;CDK2;CDKN2;Cyclin-dependent kinase 2;Cell division protein kinase 2;p33 pr
Organism-1
Human
基因ID-1
1017
SwissProt-1
P06493;P24941;Q00526
Organism-2
Mouse
基因ID-2
12534;12566
Organism-3
Rat
基因ID-3
54237
SwissProt-3
P39951;Q63699
背景
cyclin dependent kinase 1(CDK1) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
细胞定位
Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
