FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CaMKK2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
65kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human CAMKK2. AA range:381-430
特异性
CaMKIIβ Polyclonal Antibody detects endogenous levels of CaMKIIβ protein.
基因名称
CAMKK2
蛋白名称
Calcium/calmodulin-dependent protein kinase kinase 2
别名
CAMKK2;CAMKKB;KIAA0787;Calcium/calmodulin-dependent protein kinase kinase 2;CaM-KK 2;CaM-kinase kinase 2;CaMKK 2;Calcium/calmodulin-dependent protein kinase kinase beta;CaM-KK beta;CaM-kinase kinase beta;CaMKK beta
Organism-1
Human
基因ID-1
10645
SwissProt-1
Q96RR4
Organism-2
Mouse
基因ID-2
207565
SwissProt-2
Q8C078
Organism-3
Rat
基因ID-3
83506
SwissProt-3
O88831
背景
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012],
细胞定位
Nucleus . Cytoplasm . Cell projection, neuron projection . Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. .
