FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CA VIII
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
33kD
推荐稀释比
IHC: 100-300;WB 1:500-1:2000;ELISA 1:40000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from the Internal region of human CA VIII.
特异性
CA VIII Polyclonal Antibody detects endogenous levels of CA VIII protein.
基因名称
CA8
蛋白名称
Carbonic anhydrase-related protein
别名
CA8;CALS;Carbonic anhydrase-related protein;CARP;Carbonic anhydrase VIII;CA-VIII
Organism-1
Human
基因ID-1
767
SwissProt-1
P35219
Organism-2
Mouse
基因ID-2
12319
SwissProt-2
P28651
Organism-3
Rat
基因ID-3
297814
SwissProt-3
Q5PPN4
背景
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provid
细胞定位
cytoplasm,
