FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
BRCA2
反应性
Human,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
384kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human BRCA2. AA range:31-80
特异性
BRCA2 Polyclonal Antibody detects endogenous levels of BRCA2 protein.
基因名称
BRCA2
蛋白名称
Breast cancer type 2 susceptibility protein
别名
BRCA2;FACD;FANCD1;Breast cancer type 2 susceptibility protein;Fanconi anemia group D1 protein
Organism-1
Human
基因ID-1
675
SwissProt-1
P51587
Organism-2
Mouse
SwissProt-2
P97929
Organism-3
Rat
SwissProt-3
O35923
背景
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],
细胞定位
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with ERCC5/XPG to nuclear foci following DNA replication stress. .
