FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
BCSC-1
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
86kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420
特异性
BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein.
基因名称
VWA5A
蛋白名称
von Willebrand factor A domain-containing protein 5A
别名
VWA5A;BCSC1;LOH11CR2A;von Willebrand factor A domain-containing protein 5A;Breast cancer suppressor candidate 1;BCSC-1;Loss of heterozygosity 11 chromosomal region 2 gene A protein
Organism-1
Human
基因ID-1
4013
SwissProt-1
O00534
Organism-2
Mouse
SwissProt-2
Q99KC8
背景
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.
细胞定位
nucleus,nucleoplasm,
