FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
BCAR3
反应性
Human,Rat,Mouse,
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
92kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human BCAR3. AA range:761-810
特异性
BCAR3 Polyclonal Antibody detects endogenous levels of BCAR3 protein.
基因名称
BCAR3
蛋白名称
Breast cancer anti-estrogen resistance protein 3
别名
BCAR3;NSP2;SH2D3B;Breast cancer anti-estrogen resistance protein 3;Novel SH2-containing protein 2;SH2 domain-containing protein 3B
Organism-1
Human
基因ID-1
8412
SwissProt-1
O75815
Organism-2
Mouse
SwissProt-2
Q9QZK2
背景
breast cancer anti-estrogen resistance 3(BCAR3) Homo sapiens Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],
细胞定位
Cytoplasm . Cell junction, focal adhesion . Localization to focal adhesions depends on interaction with PTPRA. .
