FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
AZ1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
25kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:40000;WB 1:500-2000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
特异性
AZ1 Polyclonal Antibody detects endogenous levels of AZ1 protein.
基因名称
OAZ1
蛋白名称
Ornithine decarboxylase antizyme 1
别名
OAZ1;OAZ;Ornithine decarboxylase antizyme 1;ODC-Az
Organism-1
Human
基因ID-1
4946
SwissProt-1
P54368
Organism-2
Mouse
基因ID-2
18245
SwissProt-2
P54369
Organism-3
Rat
基因ID-3
25502
SwissProt-3
P54370
背景
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms
细胞定位
nucleus,cytoplasm,cytosol,
