FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ATBF1
反应性
Human,Mouse
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
404kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human ZFHX3. AA range:761-810
特异性
ATBF1 Polyclonal Antibody detects endogenous levels of ATBF1 protein.
基因名称
ZFHX3
蛋白名称
Zinc finger homeobox protein 3
别名
ZFHX3;ATBF1;Zinc finger homeobox protein 3;AT motif-binding factor;AT-binding transcription factor 1;Alpha-fetoprotein enhancer-binding protein;Zinc finger homeodomain protein 3;ZFH-3
Organism-1
Human
基因ID-1
463
SwissProt-1
Q15911
Organism-2
Mouse
SwissProt-2
Q61329
背景
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
细胞定位
Nucleus . Cytoplasm . Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body. .
