FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Arkadia
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
110kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950
特异性
Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.
基因名称
RNF111
蛋白名称
E3 ubiquitin-protein ligase Arkadia
别名
RNF111;E3 ubiquitin-protein ligase Arkadia;RING finger protein 111
Organism-1
Human
基因ID-1
54778
SwissProt-1
Q6ZNA4
Organism-2
Mouse
基因ID-2
93836
SwissProt-2
Q99ML9
背景
ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
细胞定位
Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol. .
